health department

Interventions that promote longevity, remembered by mnemonic: DEEP purple - “eat colorful plant foods: D ietary modification, E xercise, active E ngagement, P urposeful living (click here to enlarge the image ). Based on a Mayo Clinic Proceedings article ( https://www.mayoclinicproceedings.org/article/S0025-6196(18)30792-4/ ): Exceptional Human Longevity : the oldest old have an extreme phenotype of delayed onset of age-related diseases and/or resistance to lethal illnesses occurring earlier in life. Centenarians have delayed onset of chronic diseases During the span of human history the likelihood of living from birth to age 100 rose from 1 in 20 million to 1 in 50 as of year 1995 (for females in low-mortality nations such as Japan and Sweden). By 2009, this probability increased to 1 in 2. About 1 in 5,000 persons in the United States is a centenarian or older. Human longevity now exceeds 115 years. However, maximum life span has remained largely unchanged. There is a limit to huma...

Epigenetics "Tthere is nobody who disputes that epigenetics predicts life span”. Aging eight or more years faster than your calendar age equates to twice the typical risk of dying, while aging seven years slower is associated with half the risk of death, Horvath says. "Life span predictor" clock His lab has developed a "life span predictor" they named it after the Grim Reaper: DNAm GrimAge. The epigenetic clock is more accurate the younger a person is. It’s especially inaccurate for the very old. “At this point, we don’t have any evidence that it’s clinically useful, because there are big error bars.” Seed of the clock is strongly influenced by underlying genes: 40% of the ticking rate is determined by genetic inheritance, and the rest by lifestyle and luck: " I'LL do it" mnemonic: I nheritance L ifestyle L uck Eating a healthy diet including lots of vegetables and fish is associated with slower epigenetic aging. Sleep deprication speeds the cloc...